#Dynamic duo trial

Of the 21 patients treated, nine previously either had stable disease or responded to single-agent immunotherapy before becoming resistant to this treatment.

#Dynamic duo trial

“What’s unique about our trial is that it’s two completely different types of drugs that have never been combined in humans before, and the trial demonstrated that these drugs can be safely administered, and also, there’s evidence that it may help patients where checkpoint therapy is not good enough alone,” says Rubinstein.

Wrangle and Rubinstein’s therapy is a combination of a checkpoint drug, nivolumab, with a new and powerful immune stimulation drug, ALT-803 (Altor Bioscience, Miramar, FL). “What’s unique about the therapy that we’re testing is that, in addition to cutting the brake cables on white blood cells, we’re providing fuel to them so that they can more effectively kill cancer cells.” “Tumor cells often produce suppressive factors that essentially put the brakes on tumor-killing white blood cells,” explains Rubinstein. Checkpoint therapies work by cutting the brake cables on the white bloods cells that are inherently able to kill tumor cells. Patients with metastatic non-small cell lung cancer will always progress after chemotherapy, so most patients go on to be treated with checkpoint immunotherapy. Rubinstein, Ph.D., also of the Hollings Cancer Center, Wrangle designed a clinical trial that started in 2016. “And at the very least we have a significant proportion of patients enjoying prolonged survival, even if we can’t call them cured.”Īlong with immunologist Mark P. We now get to flirt with the idea for certain patients using immunotherapy,” says Wrangle. “People don’t talk about curing patients with metastatic lung cancer. Wrangle, M.D., a medical oncologist at the MUSC Hollings Cancer Center, says it’s a promising therapy that can be delivered in an outpatient setting. The study, published in the May issue of The Lancet Oncology, focused on non-small cell lung cancer, which is the most common form of lung cancer. Recent results from a clinical trial to treat lung cancer show that a novel immunotherapy combination is surprisingly effective at controlling the disease’s progression. Turn it up a notch to 10 grams and you can expect a medium trip with visuals.Novel immunotherapy combination for lung cancer shows promise of success Although at this dose, there likely won’t be visuals since the strain is rather mild. Her sidekick Pajaritos (Spanish for 'little birds', referring to the small size of the individual sclerotium) complements her buddy perfectly with similar effects.ĥ grams of this cocktail of 2 strains will be enough so you can get a twisted new view on reality. This is a variety that is all about giving you an awesome, happy, and creative experience. Mexicana has been used by indigenous peoples for centuries. Our Dynamic Duo Magic Truffles Pack contains both Mexicana and Pajaritos for a total of 25 grams of magic truffles in one double pack!

EFFECTS OF THE MAGIC TRUFFLES 'DYNAMIC DUO' So expect a moderate trip that is also very well-suited for a nice first experience. On a scale from 1 to 5, we’d say that each is nestled right in the middle at about 2.5. Meet our Dynamic Duo of magic truffles! The popular Mexicana and “little birds” Pajaritos join forces to provide you with a happy and creative psychedelic journey! Both of these psilocybin-containing truffle strains in our Dynamic Duo pack are rather mild-but do not underestimate them. Zamnesia - Dynamic Duo: 2-In-1 Truffle Double Feature